Aspectos necroscópicos de morte súbita em decorrência de cardiomiopatia hipertrófica congênita (CHC): Relato de Caso

Mariane Amaral Silva; Gabriela Silva Faria; Ana Luísa Souki Parreira Souki Parreira; Andressa Vinha Zanúncio

doi:10.15260/rbc.v14i2.910

Case Report: Necropsy Aspects of Sudden Death Due to Congenital Hypertrophic Cardiomyopathy

Vol. 14 No. 2 (2025)
134-140
11/11/2024
21/07/2025
10.15260/rbc.v14i2.910

Abstract

Objective: To report a case of death following an assault involving a frontal injury, discussing the findings described in the
autopsy reports, which revealed sudden death as the cause of death. Case Description: The subject was a male who suffered a
punch to the frontal region and died at the scene. Autopsy findings were incompatible with death caused by external trauma, as
the injuries were non-lethal. The investigation led to a diagnosis of hypertrophic cardiomyopathy, an autosomal dominant genetic disorder affecting cardiac proteins, resulting in structural changes that may lead to sudden death in some patients. Final Considerations: The autopsy findings allowed concluding that the cause of death was associated with the presence of cardiac disease, although it did not exclude the association with the violent event.
Keywords: sudden death, congenital hypertrophic cardiomyopathy, cardiac pathology.

References

E. Arbelo; A. Protonotarios; J.R. Gimeno; et al. 2023 ESC Guidelines for the management of cardiomyopathies: Developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC). Eur. Heart J. 44: 3503-3626 (2023).
M.S. Maron; W.J. McKenna; T.F. Dardas. Cardiomiopatia hipertrófica: manifestações clínicas, diagnóstico e avaliação. UpToDate 1-10 (2022).
M.S. Maron; S. Lévy; W.J. McKenna; T.F. Dardas. Cardiomiopatia hipertrófica: Gestão de arritmias ventriculares e risco de morte cardíaca súbita. UpToDate 1-10 (2024).
V. Cianci; E. Forzese; D. Sapienza; L. Cardia; A. Cianci; A. Germanà; L. Tornese; A. Ieni; P. Gualniera; A. Asmundo; et al. Morphological and genetic aspects for post-mortem diagnosis of hypertrophic cardiomyopathy: a systematic review. Int. J. Mol. Sci. 25: 1275 (2024). Retirado em 19/04/2025, de https://doi.org/10.3390/ijms25021275.
E. Arteaga-Fernández; M.O. Antunes. Prevention of Sudden Death in Hypertrophic Cardiomyopathy. Arq. Bras. Cardiol. 110(6): 532-533 (2018). Retirado em 19/04/2025, de https://doi.org/10.5935/abc.20180101.
M.A.B. Oliveira. Cardiomiopatia hipertrófica, atividade física e morte súbita. Rev. Bras. Med. Esporte 8(1): 20-25 (2002). Retirado em 19/04/2025, https://doi.org/10.1590/S1517-86922002000100004.
F. Fernandes; M.V. Simões; E.B. Correia; F.G. Marcondes-Braga; O.R.C. Filho; C.T. Mesquita; W. Mathias Jr.; et al. Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024. Arq. Bras. Cardiol. 121(7): e202400415 (2024).
G.V. França. Medicina legal [recurso online]. 11ª ed. Rio de Janeiro: Guanabara Koogan (2017). ISBN: 9788527732284.
P.G. Lopes; et al. Prevenção de hematoma subgaleal pós-operatório. Técnica de curativo. Arq. Bras. Neurocir. 22(1-2): 8-11 (2003). Retirado em 21/04/2025, de https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0038-1625089.pdf.